Tetrahydrocannabinol (THC)
/tet-ruh-hy-dro-kuh-NAB-ih-nol/
The primary psychoactive cannabinoid in cannabis. A partial agonist at CB1 and CB2 receptors.
In Depth
Δ9-THC (delta-9-tetrahydrocannabinol) is the most pharmacologically studied cannabinoid. Its psychoactive effects result from CB1 receptor agonism in the brain, particularly in the prefrontal cortex, hippocampus, basal ganglia, and cerebellum. THC has a biphasic dose-response relationship for anxiety: low doses (2.5–5mg) may be anxiolytic, while higher doses frequently produce anxiety and paranoia. Medically, THC is approved (as dronabinol/Marinol) for chemotherapy-induced nausea and AIDS-related anorexia.
Further Reading
More in Cannabinoids
Cannabidiol (CBD)
A non-intoxicating phytocannabinoid found in Cannabis sativa. The second most abundant cannabinoid in most cannabis strains.
Cannabigerol (CBG)
A non-intoxicating cannabinoid often called the "mother cannabinoid" — the biosynthetic precursor from which THC, CBD, and CBC are synthesized.
Cannabinol (CBN)
A mildly psychoactive cannabinoid formed by the oxidative degradation of THC. Accumulates as cannabis ages or is exposed to heat and light.
Cannabichromene (CBC)
A non-intoxicating phytocannabinoid that does not bind significantly to CB1 or CB2 receptors but interacts with TRP channels.
Phytocannabinoid
Any cannabinoid produced naturally by the cannabis plant. Distinct from endocannabinoids (produced by the body) and synthetic cannabinoids.