Insights
Long-form research explainers, clinical guides, and policy analysis — written for patients, caregivers, and healthcare professionals.
CBD vs. THC: Key Clinical Differences Every Patient Should Know
CBD and THC are the two most studied cannabinoids, but they have fundamentally different pharmacological profiles, evidence bases, and safety considerations. This article provides a clear clinical comparison to help patients and providers make informed decisions.
April 22, 2026
How to Read Cannabis Research: A Critical Appraisal Guide
Cannabis research is growing rapidly, but quality varies enormously. This guide teaches you to distinguish strong evidence from weak, identify common methodological problems, and understand why "a study showed" headlines often tell only part of the story.
May 1, 2026
Schedule I and the Research Gap: How Federal Law Shapes Cannabis Science
Cannabis remains Schedule I under US federal law — the most restrictive drug classification. This creates enormous barriers to research, limiting the quality and quantity of clinical evidence. This article explains what Schedule I means in practice, how it affects research, and what the proposed rescheduling to Schedule III would change.
May 8, 2026
Terpenes: Beyond the Entourage Effect Hype
Terpenes are the aromatic compounds that give cannabis its distinctive smell and flavor. They are widely marketed as key contributors to cannabis's therapeutic effects via the "entourage effect." But what does the science actually say? This article separates evidence from marketing.
May 14, 2026
CBD Drug Interactions: A Clinical Reference Guide
CBD is a potent inhibitor of multiple CYP enzymes, creating clinically significant drug interactions with dozens of commonly prescribed medications. This guide covers the mechanisms, affected drug classes, and monitoring recommendations for clinicians and patients.
May 20, 2026
Cannabis and the Adolescent Brain: What the Research Shows
The adolescent brain is uniquely vulnerable to cannabis. The endocannabinoid system plays a critical role in brain development, and disrupting it during adolescence with exogenous cannabinoids may have lasting consequences. This article reviews the evidence on cannabis and adolescent neurodevelopment.
May 26, 2026
Medical Cannabis Dosing: A Practical Guide for Patients
Dosing medical cannabis is more complex than most medications because of the wide variability in products, routes of administration, and individual responses. This practical guide explains the "start low, go slow" principle, how to titrate, and what to expect.
May 30, 2026
Cannabis and the Opioid Crisis: Evidence, Promise, and Caution
The opioid crisis has killed hundreds of thousands of Americans. Cannabis has been proposed as an opioid substitute or adjunct that could reduce opioid use and overdose deaths. This article examines the evidence — which is more complex and less definitive than headlines suggest.
June 2, 2026
CBG: The "Mother Cannabinoid" and Its Emerging Research Profile
Cannabigerol (CBG) is the biosynthetic precursor to THC, CBD, and CBC — earning it the nickname "mother cannabinoid." It is present in low concentrations in most cannabis strains but is attracting growing research interest for its unique pharmacological profile. This article reviews the current evidence.
June 3, 2026