SG
Neuroimaging5 Active Trials

Staci Gruber, PhD

Associate Professor of Psychiatry; Director, Marijuana Investigations for Neuroscientific Discovery (MIND)

McLean Hospital / Harvard Medical School · Belmont, Massachusetts, USA

h-index 48
9,200+ citations
142+ publications
5 active trials

Biography

Staci Gruber directs the MIND (Marijuana Investigations for Neuroscientific Discovery) program at McLean Hospital, one of the most comprehensive longitudinal neuroimaging studies of cannabis effects in the United States. Her research uses fMRI, structural MRI, and neuropsychological testing to characterize how cannabis affects brain structure and function across different use patterns. Gruber has been particularly influential in distinguishing the effects of recreational cannabis from medical cannabis, finding that medical cannabis patients often show cognitive improvements over time.

Key Contributions

  • 1Established the MIND longitudinal neuroimaging cohort for cannabis research
  • 2Demonstrated that medical cannabis patients show cognitive improvements over 3 months of use
  • 3Characterized white matter microstructure changes associated with early-onset cannabis use
  • 4Showed that age of onset is a critical variable in cannabis-related brain changes
  • 5Developed neuroimaging biomarkers for cannabis use disorder severity

Selected Publications

Splendor in the grass? A pilot study assessing the impact of medical marijuana on executive function

312 citations

Frontiers in Pharmacology · 2016

Prospective study finding that medical cannabis patients showed improvements in executive function, attention, and mood after 3 months of use, contrasting with recreational user data.

DOI: 10.3389/fphar.2016.00355

Age of onset of marijuana use and executive function in adolescence and young adulthood

489 citations

Drug and Alcohol Dependence · 2012

Demonstrated that earlier age of cannabis onset was associated with greater executive function deficits, with those beginning before age 16 showing the most pronounced impairment.

DOI: 10.1016/j.drugalcdep.2011.09.019
View all publications on PubMed