Cannabinoid Pharmacology

Roger Pertwee, PhD, DSc, FBPhS, FRSE

Emeritus Professor of Neuropharmacology

University of Aberdeen · Aberdeen, Scotland, UK

h-index 88

41,000+ citations

320+ publications

0 active trials

PubMed Profile ORCID

Biography

Roger Pertwee is one of the most cited cannabinoid pharmacologists in the world and a pioneer in characterizing the pharmacology of cannabinoid receptors and their ligands. His laboratory at the University of Aberdeen has made seminal contributions to understanding CB1 and CB2 receptor pharmacology, the mechanisms of action of THC and CBD, and the development of cannabinoid receptor ligands as research tools and potential therapeutics. Pertwee has authored over 300 peer-reviewed publications and is a Fellow of the Royal Society of Edinburgh.

Key Contributions

1Characterized the pharmacology of CB1 and CB2 receptors in landmark studies
2Demonstrated that CBD is a negative allosteric modulator of CB1 receptors
3Developed the pharmacological classification system for cannabinoid receptor ligands
4Identified the mechanisms underlying THC's psychoactive and therapeutic effects
5Edited the definitive textbook "Cannabinoids" (Handbook of Experimental Pharmacology)

Selected Publications

Pharmacology of cannabinoid CB1 and CB2 receptors

3,241 citations

Pharmacology & Therapeutics · 1997

Comprehensive review of CB1 and CB2 receptor pharmacology, distribution, and signaling mechanisms that became a foundational reference for the field.

DOI: 10.1016/S0163-7258(97)82001-3

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

1,876 citations

British Journal of Pharmacology · 2008

Comparative pharmacological analysis of THC, CBD, and THCV at CB1 and CB2 receptors, establishing the distinct receptor profiles of these three major phytocannabinoids.

DOI: 10.1038/sj.bjp.0707442

View all publications on PubMed