Louise Turner Arnold Chair in Neurosciences; Professor of Anatomy & Neurobiology
University of California, Irvine · Irvine, California, USA
Daniele Piomelli is one of the world's leading authorities on the endocannabinoid system and lipid-based neurotransmission. His laboratory at UC Irvine has made foundational contributions to understanding how endocannabinoids are synthesized, released, and degraded, and how these processes can be targeted therapeutically. Piomelli's work on FAAH (fatty acid amide hydrolase) inhibitors — enzymes that degrade anandamide — has opened a new class of potential non-intoxicating analgesics and anxiolytics. He is the founding editor of the journal Cannabis and Cannabinoid Research.
Trends in Pharmacological Sciences · 2014
Review of endocannabinoid system pharmacology as a therapeutic target for anxiety and depression, focusing on FAAH inhibition as a strategy to enhance anandamide signaling without direct CB1 agonism.
DOI: 10.1016/j.tips.2014.01.002Journal of Neuroscience · 1999
Landmark study mapping FAAH distribution throughout the brain and characterizing its role in anandamide degradation, establishing FAAH as a key regulator of endocannabinoid tone.
DOI: 10.1523/JNEUROSCI.19-09-03462.1999