Search results for "THC pain"
20 results across studies, Q&A, topic hubs, and guides
THC:CBD Ratio Effects on Chronic Pain Management in Cancer Patients
Balanced THC:CBD formulations showed superior pain reduction vs. THC-only preparations in a 6-month RCT of 312 patients with cancer-related chronic pain.
Chronic Pain Research Hub
489 indexed studies covering neuropathic pain, cancer pain, fibromyalgia, and musculoskeletal pain. Includes dosing protocols and clinical guidelines.
THC (Δ9-Tetrahydrocannabinol) — Compound Profile
Comprehensive pharmacology of THC — CB1/CB2 agonism, therapeutic uses (CINV, MS spasticity, neuropathic pain), drug interactions, and 8,400+ indexed studies.
Is THC neuroprotective or neurotoxic at therapeutic doses?
The evidence is dose- and context-dependent. Low-dose THC shows neuroprotective properties in some models; high-dose or chronic exposure is associated with neurotoxic effects, particularly in developing brains.
Understanding CBD vs. THC: What the Science Says
A plain-language guide to the differences between CBD and THC — how they interact with the endocannabinoid system, their distinct effects, and what research says about their therapeutic applications.
Clinical Dosing Guidelines for Healthcare Providers
Evidence-based dosing protocols for medical cannabis and cannabinoid medications. Covers starting doses, titration schedules, and monitoring parameters by condition.
For Healthcare Professionals: Clinical Resources Portal
Clinical protocols, drug interaction database, dosing frameworks, and CME education for physicians, pharmacists, and allied health professionals.
Ziva Cooper, PhD — Researcher Profile
Director, UCLA Cannabis Research Initiative. CBD-THC interaction research. Demonstrated cannabis reduces opioid consumption. Sex differences in cannabis pharmacology.
What does current research say about cannabis and sleep quality?
Short-term use may improve sleep onset, but evidence for long-term benefit is limited. THC suppresses REM sleep; CBD shows more promise for anxiety-related insomnia without REM disruption.
Cardiovascular Health Research Hub
890 studies on cannabinoid effects on the heart and vasculature — including THC-induced tachycardia, MI risk, CBD blood pressure effects, and cardiac arrhythmia.
Cannabinoid Pharmacology Research Hub
Bioavailability, metabolism, CYP450 interactions, and pharmacokinetics of THC, CBD, and minor cannabinoids across all routes of administration.
CBN (Cannabinol) — Compound Profile
THC degradation product — mildly psychoactive, widely marketed as a sleep aid despite limited clinical evidence. Promising antibacterial and ALS neuroprotection data.
Raphael Mechoulam, PhD — Researcher Profile
"Father of cannabis research." Isolated THC (1964), CBD (1963), and anandamide (1992). Proposed the entourage effect. h-index 98, 62,000+ citations.
Mark Ware, MBBS — Researcher Profile
Led COMPASS long-term safety study of medical cannabis. First RCT of smoked cannabis for neuropathic pain. Shaped Canadian cannabis legalization policy. McGill University.
Cannabis Clinical Trials Tracker
30+ active, recruiting, and completed cannabis clinical trials — filterable by condition, phase, compound, and status. NCT IDs with direct ClinicalTrials.gov links.
Donald Abrams, MD — Researcher Profile
Pioneer in cannabis and oncology. First FDA-approved cannabis trial in HIV patients. RCT of cannabis for HIV neuropathy (Neurology 2007). UCSF integrative oncology.
Fact vs. Fiction: Common Cannabis Claims Examined
We examine 20 of the most common claims about cannabis — from "CBD cures cancer" to "marijuana is not addictive" — against the current peer-reviewed evidence.
Cancer & Oncology Research Hub
267 studies on cannabinoids in oncology. Covers anti-tumor mechanisms, chemotherapy-induced nausea, pain management, and palliative care applications.
CBG (Cannabigerol) — Compound Profile
The "mother cannabinoid" — biosynthetic precursor to THC and CBD. Antibacterial against MRSA, neuroprotective in Huntington's disease models, anti-inflammatory in IBD.
Ethan Russo, MD — Researcher Profile
Proposed clinical endocannabinoid deficiency (CECD). Authored "Taming THC" — the foundational entourage effect review. Former GW Pharmaceuticals. Terpene pharmacology expert.