Search results for "Drug interactions"
10 results across studies, Q&A, topic hubs, and guides
Drug Interactions Database
Evidence-based interaction data for cannabinoids and 200+ medications. Includes CYP450 pathway analysis, clinical significance ratings, and management recommendations.
Does CBD interact with SSRIs and antidepressants?
CBD is metabolized by CYP2D6 and CYP3A4 enzymes, which also process many SSRIs. Current evidence suggests potential for increased SSRI plasma levels, though clinical significance varies by drug and dose.
Can cannabis use affect chemotherapy outcomes?
Emerging evidence suggests cannabinoids may have anti-tumor properties in preclinical models, but clinical data on chemotherapy interactions is limited. Drug interactions with chemotherapy agents are a significant concern.
For Healthcare Professionals: Clinical Resources Portal
Clinical protocols, drug interaction database, dosing frameworks, and CME education for physicians, pharmacists, and allied health professionals.
Terpene Entourage Effects: A Systematic Review of Synergistic Cannabinoid Interactions
Review of 31 studies found mixed evidence for the entourage effect. Myrcene and linalool showed the most consistent synergistic activity with CBD in preclinical models.
THC (Δ9-Tetrahydrocannabinol) — Compound Profile
Comprehensive pharmacology of THC — CB1/CB2 agonism, therapeutic uses (CINV, MS spasticity, neuropathic pain), drug interactions, and 8,400+ indexed studies.
CBD (Cannabidiol) — Compound Profile
Comprehensive pharmacology of CBD — 5-HT1A, TRPV1, GPR55 mechanisms, FDA-approved Epidiolex, drug interactions (CYP3A4/2C9), and 6,200+ indexed studies.
Cannabinoid Pharmacology Research Hub
Bioavailability, metabolism, CYP450 interactions, and pharmacokinetics of THC, CBD, and minor cannabinoids across all routes of administration.
Cannabis Terpenes — Compound Profile
Myrcene, limonene, linalool, β-caryophyllene, α-pinene — pharmacology, the entourage effect, and 1,100+ studies on terpene-cannabinoid interactions.
Vincenzo Di Marzo, PhD — Researcher Profile
Coined the "endocannabinoidome." Elucidated endocannabinoid biosynthesis and gut microbiome interactions. h-index 112, 82,000+ citations. Université Laval.