Retrograde Signaling
A form of synaptic communication where the postsynaptic neuron sends chemical signals back to the presynaptic neuron to modulate neurotransmitter release.
In Depth
Endocannabinoids are the primary retrograde messengers in the CNS. When a postsynaptic neuron is strongly activated, it synthesizes endocannabinoids (primarily 2-AG) that travel backward across the synapse to activate CB1 receptors on the presynaptic terminal. This reduces neurotransmitter release — a process called depolarization-induced suppression of inhibition (DSI) or excitation (DSE). This mechanism allows neurons to regulate their own incoming signals and is fundamental to synaptic plasticity.
Related Terms
Further Reading
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