What dose of CBD is effective for anxiety?

Clinical trials demonstrating anxiolytic effects have used single doses of 300–600mg CBD. This is substantially higher than the 10–50mg found in most commercial CBD products. A 2019 RCT (Masataka, Frontiers in Psychology) found 300mg effective for social anxiety in a public speaking test. The 2011 Crippa et al. fMRI study used 400mg. Chronic dosing studies are limited — most evidence is from single-dose paradigms. The clinical relevance of low-dose commercial CBD for anxiety remains unestablished. For context, Epidiolex (FDA-approved CBD) is dosed at 5–20mg/kg/day for epilepsy, which translates to 350–1,400mg/day for a 70kg adult.